We asked the global drug discovery community to vote on their favorite molecule from 2020, and the results are in. The community’s 2020 choice for Small Molecule of the Year is GS-6207 (lenacapavir), the awe-inspiring HIV capsid inhibitor published by Gilead Sciences in a 2020 issue of Nature. The GSK RIPK2 PROTAC degrader received the …
For the first installment of Drug Hunter’s “Small Molecules of the Month” series in 2021, we have a Kissei SGLT2 inhibitor whose lead was a metabolite found in mouse urine, a GSK integrin inhibitor that was found to trigger lysosomal degradation, and the first non-sugar OGA inhibitor derived from a Takeda virtual screen. Plenty of …
On Feb. 16, 12:00PM PST, I’ll be hosting Dr. Mira Pochon, Staff Scientist and Head of Translational Biology at Global Blood Therapeutics, for a PBSS/CLSA webinar on one of my favorite 2019 drug approvals, voxelotor (GBT440). Mira has been with GBT since it’s early days in 2011, and will be able to tell the whole …
In 2020 the Drug Hunter site highlighted >150 “molecules of the month” whose structures or stories were typically published for the first time. They were selected from thousands of research articles, published by leading institutions around the world. It was incredibly hard to narrow down the selection to just one molecule from each month, and …
Assume a cow is an evenly distributed sphere… sometimes. I happened to take an animal physiology course in college because my girlfriend (now wife) needed it for her biology major and taking a class together about bird metabolism was my idea of a nice date. I had no idea it would end up being one …
Happy 2021! Here’s the last installment of Small Molecules of the Month for 2020. It was so hard to narrow this down to one sheet of molecules since there were so many timely publications in December. One of my favorites this month is an oral(!) ultra-long acting insulin derivative from Novo which demonstrated human efficacy …