For the first installment of Drug Hunter’s “Small Molecules of the Month” series in 2021, we have a Kissei SGLT2 inhibitor whose lead was a metabolite found in mouse urine, a GSK integrin inhibitor that was found to trigger lysosomal degradation, and the first non-sugar OGA inhibitor derived from a Takeda virtual screen. Plenty of …
In 2020 the Drug Hunter site highlighted >150 “molecules of the month” whose structures or stories were typically published for the first time. They were selected from thousands of research articles, published by leading institutions around the world. It was incredibly hard to narrow down the selection to just one molecule from each month, and …
Happy 2021! Here’s the last installment of Small Molecules of the Month for 2020. It was so hard to narrow this down to one sheet of molecules since there were so many timely publications in December. One of my favorites this month is an oral(!) ultra-long acting insulin derivative from Novo which demonstrated human efficacy …
Hope everyone had a fantastic Christmas weekend. Last month there were quite a few large small molecules, including three macrocycles. Quite a few of these molecules would’ve made for a decent synthesis PhD project! Some highlights include a cryo-EM structure for Chugai/Lilly’s GLP-1R agonist, a Ra Pharma mRNA display screen yielding a PCSK9 PPI inhibitor, …
Hope everyone is having a great US Thanksgiving week. This month’s update features quite a few contributions from international companies, including three from Bayer in Germany, a double soft drug from Leo Pharma in Denmark, and others from sites in Poland, Belgium, Spain, China, and India. Links to Articles: BAY 1214784 (Bayer oral hGnRH-R hormone …
This was a loaded month for pioneering drug discovery programs! Among the highlights are a reversible-covalent inhibitor from Novartis, the hotly followed SHP2 inhibitor from Novartis, several innovative compounds from Pfizer including an oral GLP-1R agonist with a cryo-EM structure, a liver-targeted ACC inhibitor, and an oral KHK inhibitor. Remarkably, half of the molecules are …